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Since 1999, the Delta Blues Museum has been housed in the historic Clarksdale freight depot, built in 1918 for the Yazoo and Mississippi Valley Railroad. The building was designated a Mississippi Landmark Property in 1996. The former freight area and the adjacent Muddy Waters expansion – about seven thousand square feet of ground floor space – is devoted to permanent and traveling exhibits.

A 2013 recipient of the IMLS National Medal for Museum and Library Services – the nation’s highest honor for museum and library service to the community – as well as a 2014 winner of the National Arts & Humanities Youth Program Award, the Delta Blues Museum is dedicated to creating a welcoming place where visitors find meaning, value and perspective by exploring the history and heritage of the unique American musical art form, the Blues, as a Great River Road Interpretive Center.